PROBLEM TO BE SOLVED: To provide a medicine improving symptoms peripheral to dementia a medicine improving irascibility, irritability and/or impulsivity a medicine adjusting the action of an antipsychotic drug, mood-stabilizing drug and/or antianxiety drug and a medicine adjusting the action of blonanserin these medicines having excellent pharmacological activity.SOLUTION: The medicine improving symptoms peripheral to dementia, the medicine improving irascibility, irritability and/or impulsivity, the medicine adjusting the action of an antipsychotic drug, mood-stabilizing drug and/or antianxiety drug and the medicine adjusting the action of blonanserin each includes clomipramine or a pharmaceutically acceptable salt thereof as an active ingredient.COPYRIGHT: (C)2012,JPO&INPIT【課題】優れた薬理活性を有する認知症周辺症状改善剤、易怒性,被刺激性及び/又は衝動性改善剤、抗精神病薬,気分安定薬及び/又は抗不安薬の作用調整剤、並びに、ブロナンセリン作用調整剤を得る。【解決手段】クロミプラミン又はその薬学的に許容される塩を有効成分とする認知症周辺症状改善剤、易怒性,被刺激性及び/又は衝動性改善剤、抗精神病薬,気分安定薬及び/又は抗不安薬の作用調整剤、並びに、ブロナンセリン作用調整剤。【選択図】なし