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SUBSTITUTED QUINAZOLINES
专利权人:
SHIRE LLC
发明人:
BERNARD GOLDING,RICHARD FRANKLIN
申请号:
BRPI0912672
公开号:
BRPI0912672A2
申请日:
2009.05.13
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
This invention relates to the discovery of substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below wherein the substituents have the meanings defined in claim 1: and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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