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COMBINATION
专利权人:
НОВАРТИС АГ (CH)
发明人:
КУМАР Ракеш (US)
申请号:
RU2015119226
公开号:
RU2015119226A
申请日:
2013.10.21
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A combination comprising: (i) a compound of structural formula (I): or a pharmaceutically acceptable salt thereof; and (ii) a compound of structural formula (II): or a pharmaceutically acceptable salt thereof. 2. The combination according to claim 1, wherein the compound of structural formula (I) is in the form of a monohydrochloride salt. 3. The use of a combination according to any one of paragraphs. 1 and 2 for the manufacture of a medicament or medicaments for the treatment of cancer. 4. A method for treating cancer, which comprises administering in vivo a therapeutically effective amount of a combination of 5 - [[4 - [(2,3-dimethyl-2H-indazol-6-yl) methylamino] -2-pyrimidinyl] amino] -2-methylbenzenesulfonamide or its a pharmaceutically acceptable salt, and N - {(1S) -2-amino-1 - [(3,4-difluorophenyl) methyl] ethyl} -5-chloro-4- (4-chloro-1-methyl-1H-pyrazole- 5-yl) -2-furancarboxamide or its pharmaceutically acceptable salt, to such a person where the combination is administered for a certain period, and the combination is administered for a long time. The method of claim 4, wherein the amount of 5 - [[4 - [(2,3-dimethyl-2H-indazol-6-yl) methylamino] -2-pyrimidinyl] amino] -2-methylbenzenesulfonamide or a pharmaceutically acceptable salt thereof is selected from from about 100 mg to about 1000 mg, and this amount is administered once a day in the form of one or more tablets, and the amount of N - {(1S) -2-amino-1 - [(3,4-difluorophenyl) methyl] ethyl } -5-chloro-4- (4-chloro-1-methyl-1H-pyrazol-5-yl) -2-furancarboxamide or a pharmaceutically acceptable salt thereof is selected from about 50 to about 300 mg, and this amount is administered once per day. 6. A method for treating a cancer selected from: brain cancer (glioma), glioblastoma, Banayan-Zonan syndrome, Cowden's disease, Lermitt-Duclos disease, breast cancer, edematous-infiltrative breast cancer, Wilm's tumor, Ewing sarcoma, rhabdomyosarcoma, ependioma, medulloblastoma, colon cancer1. Комбинация, сод
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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