GALLEY, GUIDO,GOERGLER, ANNICK,GROEBKE ZBINDEN, KATRIN,NORCROSS, ROGER,STALDER, HENRI
申请号：
CA2666762
公开号：
CA2666762C
申请日:
2007.10.09
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to compounds of formula (I) wherein R1 is hydrogen, lower alkyl, -(CR2)n-OH, -(CH2)n-aryl or -(CH2)n-heteroaryl, which are optionally substituted by halogen, lower alkoxy or lower alkyl substituted by halogen, or is -(CR2)n- cycloalkyl, optionally substituted by hydroxy, -(CH2)n-heterocyclyl, -(CH2)n-NH-S(O)2CH3, or is -(CR2)nO-lower alkyl or lower alkyl substituted by halogen； R is hydrogen or lower alkyl, and when two R-groups are present, they may or may not be the same； R2 is 2,2-dioxo-2,3-dihydro-1H-benzo[c]thiophenyl, 6,7-dihydro-5H-cyclopentapyrimidin-2-yl, 2,2-difluoro-benzo[1,3]dioxol-5-yl, 2,2,3,3-tetrafluoro-2,3-dihydro-benzo[1,4]dioxin-6-yl, or is aryl or heteroaryl, optionally substituted by one or more substituents, selected from the group consisting of halogen, lower alkyl, cycloalkyl, -(CH2)n-hydroxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, -S(O)2-lower alkyl, -(CH2)n-S(O)2-NH-lower alkyl, -(CH2)n-O-lower alkyl, nitro, amino, cyano, -NHC(O)-lower alkyl, -C(O)NH-lower alkyl, or O-tetrahydro-naphthalenyl, or are substituted by -(CH2)n-aryl, optionally substituted by halogen, or by -CH=CH-aryl, optionally substituted by halogen, or by -(CH2)n-O-aryl, optionally substituted by halogen, lower alkoxy or lower alkyl substituted by halogen, or by -O-(CH2)n-aryl, optionally substituted by halogen, or by -(CH2)n-heteroaryl, or by -(CH2)n-O-heteroaryl or by -(CH2)n-heterocyclyl, optionally substituted by =O, or by -(CH2)n-O-heterocyclyl, optionally substituted by lower alkyl, or by -S-aryl, -CH(OH)-aryl, -C(CH3)2-aryl, -NR-aryl, or by 2-oxo-2H-pyridin-1-yl； R3 is hydrogen or lower alkyl； R4 is hydrogen or lower alkyl； n is 0, 1, 2, 3 or 4 and to their pharmaceutically active salts for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Park
