PROBLEM TO BE SOLVED: To provide a liquid preparation capable of stably maintaining the activity of a TNFR-Fc fusion protein. A liquid formulation comprising a TNFR-Fc fusion protein, a mixture of proline and histidine, a buffer and an isotonicity agent, the fusion protein comprising TNFR (Tumor Necrosis Factor Receptor) or fragments thereof and immunization. A liquid formulation comprising a globulin Fc region. [Selection diagram] Figure 2a【課題】ＴＮＦＲ－Ｆｃ融合タンパク質の活性を安定に維持することができる液体製剤の提供。【解決手段】ＴＮＦＲ－Ｆｃ融合タンパク質、プロリンとヒスチジンとの混合物、緩衝液及び等張化剤を含む液体製剤であって、該融合タンパク質がＴＮＦＲ（腫瘍壊死因子受容体）又はそれらの断片及び免疫グロブリンＦｃ領域を含む、液体製剤。【選択図】図２ａ
