This description describes the compounds determined according to formula (1),There, R1,l1，r2，lz，R3，The cy and N sub indices are defined in this document. 1. This refers to compounds, production methods, pharmaceutical ingredients containing the same ingredients and therapeutic methods used for the prevention and / or treatment of allergic diseases, flammable diseases, metabolic diseases, spontaneous combustion diseases and autoimmune diseases, Diffuse diseases, rejection of transplantation, diseases related to deterioration of cartilage replacement, congenital malformations of cartilage and / or diseases related to IFNA hypersecretion,IL12 and / or il23 by managing current compounds. Claim 1: a compound calculated according to formula (1),Where CY is phenyl, or a heteromorphic group of 5 to 6 members, consisting of one, two or three N atoms； L1 is a simple link, or-C（=O）-C（=O）o-，-S（o）8322-，-No. 8310； - No. 7491；-C（=O）N8310；-74955-，-S (o) 8322； - No. 8310； - 758080；O-C (= O) 8310； 7496； s (o) 8322 -；R1 is: H, c832183388326 selectively uses one or more independent Oh, halo, alcox, c83218833318324；-No. 8311； No. 7491； No. 8311； No. 74955；-C（=O）Oh---C（=O）N8311；-7580；-R8311；-74966；-c（=o）o-codilo C832183318324；O monocyclic isopropyl compound, consisting of 4-8 members, including one, two or three heteroatoms independent of N, s and O； the cyclopropyl compound c8332383318327 is selectively replaced by one or more Oh, alcoxi c8332183318324；It can be composed of 4 to 9 members, including one, two or three heteroatoms independent of N, s and O, and can be replaced by one or more independently selected R11 groups； Each R1 is independent: Oh, CN, halo, oxo, - nr831222； 7491； r831222； 74955；cycloquilo C83238C83318327；a. One or more selected c83321833183242428oxy c831832424 were used for halogen-free selection；-No. 8313； No. 7491； No. 8313； No. 74955；a. Alcox c833218d83318324 is selectively replaced by alcox c833218d83312424；a. Monocyclic heterosexual, consisting of one, two or t
