Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.本發明提供用於調節標靶基因，尤其係熱休克蛋白47(hsp47)之表現之組合物、方法及套組。該等組合物、方法及套組可包括核酸分子(例如短干擾核酸(siNA)、短干擾RNA(siRNA)、雙股RNA(dsRNA)、微RNA(miRNA)或短髮夾狀RNA(shRNA))，該等核酸分子調節編碼hsp47之基因，例如編碼人類hsp47之基因。本發明所揭示之組合物及方法亦可用於治療與hsp47相關聯之病狀及病症，諸如肝纖維化、肺部纖維化、腹膜纖維化及腎纖維化。
