Arizona Board of Regents on behalf of the University of Arizona
发明人:
Ruben S. Vardanyan,Victor J. Hruby
申请号：
US15756014
公开号：
US20180235949A1
申请日:
2016.05.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides using a substituted 1-arylalkyl-4-acylaminopiperidine compound of Formula I:to treat various clinical conditions including, but not limited to, hemorrhagic shock, nicotine withdrawal symptoms, gastrointestinal side effects of opioids, cancer therapy, epithelial wounds, herpes zoster infection, or opioid-induced pruritus. In compound of Formula I, R1 is C1-10 alkyl, C1-10 haloalkyl, optionally substituted aryl, or optionally substituted heteroaryl； R2 is C1-6 alkylene； Y is optionally substituted aryl, optionally substituted heteroaryl, or a moiety of the formula —C(═O)—X1, wherein X1 is —OR3 or —NR4R5, where each of R3, R4 and R5 is H or C1-10 alkyl.
