THE REGENTS OF THE UNIVERSITY OF MICHIGAN;BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人:
Scott D. Larsen,Jessica L. Bell,Richard Neubig,Kim Hutchings
申请号：
US14642203
公开号：
US20150250769A1
申请日:
2015.03.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present disclosure relates to methods, compositions, and kits for the inhibition of signaling by members of the Rho GTPase family. Specifically, the disclosure relates to methods, compositions and kits for the inhibition of RhoA and/or RhoC transcriptional signaling and action of the transcription co-factors MRTF-A and/or MRTF-B. The disclosure finds use in treatment of Rho-mediated disease states (e.g., tumor metastasis and fibrosis), Rho-mediated biological conditions, and in cell signaling research.
