RANKL independence compared to the action which it differentiates & activates the destruction osteoclast improves, furthermore offer of the reagent which includes the fusion protein of RANKL and epitoputagu where retention stability improves. Soluble type RANKL and in the destruction osteoclast differentiation activator with of vitro which includes the fusion protein of epitoputagupepuchido as the active ingredient or in vivo.RANKL単独よりも破骨細胞を分化・活性化させる作用が向上し、さらに保存安定性が向上したRANKLとエピトープタグの融合タンパク質を含む試薬の提供。可溶型RANKLとエピトープタグペプチドの融合タンパク質を有効成分として含むin vitro又はin vivoでの破骨細胞分化・活性化剤。