A reminder system and methods may be configured for medicine regimen compliance and monitoring. Embodiments may include a control device, a medicine container, a medicine identifier attachable to the medicine container, a medicine container input device, a monitoring device having an adaptor to receive a medicine container, and a portable electrical device. The adaptor may be configured to releaseably couple the monitoring device and the medicine container. The control device, the medicine container input device and the monitoring device may include microprocessors, memories, input devices and output devices. The control device may provide operations including input and compare a prescription and medicine information. The monitoring device may provide operations including compare the medicine identifier of the medicine container and the medicine information. The monitoring device may also provide operations including determining the amount of medication removed from the medicine container. The operations may further include generate, by the output device, an alert in response to the distance exceeding a threshold.
