The present invention involves the use of 2,4-disulfonyl phenyl tert-butylnitrone (2,4-ds-PBN) in the treatmentand prevention of gliomas. The 2,4-ds-PBN may be used alone or combined withother traditional chemo- and radiotherapies andsurgery, to treat or prevent glioma occurrence, recurrence, spread, growth,metastasis, or vascularization.