GEORGETOWN UNIVERSITY;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人:
SMITH, JILL P.,STERN, STEPHAN,MAHMUD, ABDULLAH
申请号：
CA3017517
公开号：
CA3017517A1
申请日:
2017.03.15
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized； (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety； and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
