Erkki Ruoslahti;Lilach Agemy;Venkata Ramana Kotamraju
发明人:
Erkki Ruoslahti,Lilach Agemy,Venkata Ramana Kotamraju
申请号：
US12973459
公开号：
US08912136B2
申请日:
2010.12.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are compositions and methods related to clot-binding compounds. For example, disclosed are compositions comprising a surface molecule and at least one modified clot-binding compound. The modified clot-binding compound can selectively bind to clotted plasma protein, wherein the composition causes clotting and amplifies the accumulation of the composition in tumors. The modified clot-binding compound can enhance the clotting in tumors compared to its unmodified derivative. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
