PREPARATION GRANULAIRE FINE A LIBERATION PROLONGEE D'HORMONE DE CROISSANCE HUMAINE ET PROCEDE DE PRODUCTION CORRESPONDANT

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专利权人:

INDEPENDENT ADMINISTRATIVE INSTITUTION; NATIONAL INSTITUTE FOR MATERIALS SCIENCE

发明人:

OGAWA, YASUAKI,FUJII, TAKAO,MIYAMOTO, YOKO,NIIMI, JUN,IKOMA, TOSHIYUKI,TANAKA, JUNZO

申请号：

EP04745898

公开号：

EP1640019A4

申请日:

2004.06.15

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/