Dual-channel injection bipolar high frequency electrosurgical knife comprises an electrode part (10), a main part (20) and an operation part (30). The electrode part (10) comprises an active electrode (11), an insulating part (12) and an inert electrode (13). The active electrode (11) has a hollow tubular portion (111), which can cut the target lesion tissue (40) when power on. The main part (20) comprises a protective tube (24), an insulation sheath (25) and an insulation coated screw (23), connector (21), seal (22). The insulation coated screw (23) includes a conductive screw and an insulating coating on the surface. The operation part (30) comprises a positioning structure (36), a slider (33), a core rod (31), a connection sheath (32), an infusion tube (35) and a connection cable (34). 6% Luer tapers (351, 361) are attached to both the positioning structure (36) and the infusion tube (35). Liquid can flow out from the dual-channel, a solution can be injected in submucosal layer to elevate the mucous membrane tissue or clean hemorrhage site (50).