Andrew L. Lewis,Peter W. Stratford,Michael J. Driver
申请号：
US12773677
公开号：
US08465758B2
申请日:
2010.05.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method of producing an intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2′-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.
