An ophthalmic formulation is provided for the prevention and treatment of adverse ocular conditions, including presbyopia, arcus senilis, age-related macular degeneration, and other conditions associated with aging. The formulation is also useful in the prevention and treatment of other adverse ocular conditions such as those associated with oxidative and/or free radical damage within the eye these conditions can involve a condition, disease, or disorder of the cornea, retina, lens, sclera, anterior segment, or posterior segment of the eye. In one embodiment, the formulation contains at least 0.6 wt.% of a biocompatible chelating agent, an effective permeation enhancing amount of an ophthalmic permeation enhancer such as methylsulfonylmethane (MSM), an anti-AGE agent, i.e., a compound that serves to reduce the presence of advanced glycation endproducts (AGEs) in the eye, and a pharmaceutically acceptable ophthalmic carrier suited to the particular formulation type (e.g., eye drops or ointments). Preferred components of the formulation are multifunctional and naturally occurring.一種眼用調和物經提出用於預防及治療不良之眼睛狀況,包括老視(presbyopia)、老人環(arcus senilis)、年紀相關性斑狀變質、及與老化相關的其他狀況。該調和物也可用於預防和治療其他不良之眼睛狀況例如與眼內氧化性及/或自由基傷害相關聯者;此等狀況可包括眼睛的用膜、視網膜、晶狀體、鞏膜、前段、或後段的狀況、疾病、或失調症。於一具體實例中,該調和物含有至少0.6重量%的生物相容性鉗合劑,一有效穿透增強量的眼用穿透增強劑例如甲基磺醯基甲烷(MSM)、抗-AGE劑,亦即用來減少眼中高度糖化終產物(advanced glycation endproducts)(AGEs)存在之化合物,及一藥學上可接受,適配特殊調和物類型(如,眼藥水或軟膏)之眼用載劑。該調和物之較佳成分皆為多官能且為天然發生者。
