A drain tube immobilization device includes a clasp having a top body section and a bottom body section that are pivotally connected via a hinge along a first end. The clasp transitions between an open position and a closed position, and is secured in the closed position by a locking mechanism. Each of the body sections include a plurality of complimentary-oriented semicircular recesses, that form individual channels when the clasp is in the closed and locked position. Each of the channels including a shape and size that is complementary to the cross-sectional shape and size of a surgical drain tube. A malleable base member is permanently secured along the bottom of the clasp, and medical grade skin adhesive is positioned along the bottom surface of the base member.