Charles H. Sherwood,Khalid K. Sadozai,Kyle Bui,Tamara B. Gooding
申请号：
BR0318680
公开号：
BRPI0318680B1
申请日:
2003.12.23
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
"Hyaluronic acid (ha) composition, a method for increasing tissue in a patient, preparing the composition and stabilizing cross-linked hyaluronic acid (ha)". a hyaluronic acid (ha) composition includes cross-linked, water-insoluble hydrated ha gel particles. ha includes crosslinks represented by the following structural formula: ha <；39>； -u-r ~ 2 -uha <；39>；. The variables are defined in this context. a method for augmenting tissue in a patient includes inserting a needle into a patient at a site in the patient in need of tissue augmentation, where the needle is coupled to a ha-loaded syringe, and applying force to the syringe, to distribute the ha composition to the patient. One method for preparing the ha composition includes forming dehydrated, water-insoluble cross-linked ha particles, separating dehydrated, water-insoluble particles by average diameter, selecting a subset of particles by average diameter, and hydrating the subset of dehydrated particles with a physiologically compatible aqueous solution. Another method for preparing the crosslinked ha composition includes crosslinking a crosslinked ha precursor with a biscarbodimide in the presence of a ph buffer and dehydrating the crosslinked ha. Also included is a method for tissue augmentation in a patient in need of tissue augmentation. A method for stabilizing cross-linked ha includes hydrating the water-insoluble dehydrated cross-linked ha with a physiologically compatible aqueous solution including a local anesthetic, wherein the storage modulus value g <；39>； for the stabilized composition is at least about 110 ° C. % of g <；39>； value for an unstabilized composition. a stabilized ha composition is also included."composição de ácido hialurônico (ha), método para aumentar tecido em um paciente, para preparar a composição e para estabilizar ácido hialurônico (ha) reticulado". uma composição de ácido hialurônico (ha) inclui partículas de gel de ha hidratadas, insolúveis na água, reticulad
