Provided herein are antibodies that specifically bind to IL1RAP. Also described are related polynucleotides capable of encoding the provided IL1RAP-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor IL1RAP-expressing cancer progression, regression, or stability； to determine whether or not a patient should be treated for cancer； or to determine whether or not a subject is afflicted with IL1RAP-expressing cancer and thus may be amenable to treatment with an IL1RAP-specific anti-cancer therapeutic, such as the multispecific antibodies against IL1RAP and CD3 described herein.本文中提供特異性結合至IL1RAP之抗體。亦描述能夠編碼所提供之IL1RAP特異性抗體或抗原結合片段的相關多核苷酸、表現所提供之抗體或抗原結合片段的細胞、以及相關聯之載體及經可偵測標示之抗體或抗原結合片段。此外，描述使用所提供之抗體之方法。舉例而言，所提供之抗體可用來診斷、治療、或監測IL1RAP表現性癌症之進展、消退、或穩定；用來判定病患是否應該進行癌症治療；或用來判定對象是否罹患IL1RAP表現性癌症，並因而可適於以IL1RAP特異性抗癌症治療劑(諸如本文中所述之針對IL1RAP及CD3的多特異性抗體)來進行治療。
