An intra-oral system for facilitating therapeutic treatment of a patient's intra-oral musculature is provided. Also provided are methods of therapeutic treatment for intra-oral musculature. The system and methods employ a mouth piece having two or more pressure cells, such as fluid pressure cells. A patient or user applies pressure to the cells using their tongue. Wireless signals are sent to an external micro-processor, with the signals being indicative of location of pressure, degree of pressure, or both as applied to the pressure cells. A therapist may analyze pressure data as part of a therapeutic regimen.