Drexel University;Baruch S. Blumberg Institute;Hoffmann-La Roche Inc.
发明人:
Haitao Guo,Dawei Cai,Andrea Cuconati,Changhua Ji
申请号：
US15309680
公开号：
US10072047B2
申请日:
2015.06.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
