John A. Beutler,Ranjala Ratnayake,David Covell,Tanya R. Johnson
申请号：
US12811245
公开号：
US08410292B2
申请日:
2008.12.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plant Phyllanthus engleri or produced by synthetic methods. An example of the englerin derivative is 2′-chloroenglerin A, which has the structure (II), wherein double bond ‘a’ is E, Z, or a mixture of E and Z.
