Use of thermostable RNA polymerases to produce RNAs having reduced immunogenicity

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专利权人:

发明人:

Bijoyita Roy,G. B. Robb

申请号：

US15820656

公开号：

US10034951B1

申请日:

2017.11.22

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Provided herein, among other things, is a method for producing an RNA product that has reduced immunogenicity without requiring removal of any dsRNA from the RNA product. In some embodiments, the method involves transcribing a template DNA with a thermostable RNA polymerase at a temperature of greater than 44° C.

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