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An improved process for the preparation of trazodone and salts thereof.
专利权人:
PIRAMAL ENTPR LTD
发明人:
KADAM SHASHIKANT,KADAM SHASHIKANT,SOMISETTI NARENDER RAO,SOMISETTI NARENDER RAO,ASHILI SRINIVAS,ASHILI SRINIVAS,RAIGONI NARSIMULU,RAIGONI NARSIMULU
申请号:
IN203/MUM/2014
公开号:
IN2014MU00203A
申请日:
2014.01.21
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
The present invention provides an improved process for preparation of the substantially pure trazodone and its hydrochloride salt. The process comprises reaction of the compound-II (as described) with the compound-Ill (as described) optionally in the presence of an inorganic base, and a catalyst; wherein in the said process the trazodone free base and/or its hydrochloride salt are isolated by precipitation at lower temperature. The improved process for the preparation of trazodone hydrochloride (the compound I) provides the product with total amount of alkylating substances (as described herein) as impurity in less than 10 ppm. The improved process for the preparation of trazodone hydrochloride (the compound I) provides the product with total amount of l-(3-chlorophenyl)-4-(3-chloropropyl) piperazine as an impurity in less than 2.5 ppm.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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