[Problem] To provide an anti-human CD73 antibody which is potentiated compared with the conventional antibodies and has an ability to recover a suppressed function of a human T cell which is suppressed in an AMP-dependent manner. [Solution] Provided is an anti-human CD73 antibody containing: a heavy-chain variable region which contains CDR1 comprising an amino acid sequence composed of amino acid residues lying between position-31 to position-35 in SEQ ID NO: 2, CDR2 comprising an amino acid sequence composed of amino acid residues lying between position-50 to position-66 in SEQ ID NO: 2 and CDR3 comprising an amino acid sequence composed of amino acid residues lying between position-99 to position-112 in SEQ ID NO: 2； and a light-chain variable region which contains CDR1 comprising an amino acid sequence composed of amino acid residues lying between position-24 to position-34 in SEQ ID NO: 4, CDR2 comprising an amino acid sequence composed of amino acid residues lying between position-50 to position-56 in SEQ ID NO: 4, and CDR3 comprising an amino acid sequence composed of amino acid residues lying between position-89 to position-98 in SEQ ID NO: 4.
