4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors

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专利权人:

Incyte Corporation

发明人:

Yao, Wenqing,Li, Yun-long,Rodgers, James D.

申请号：

AU2008321046

公开号：

AU2008321046B2

申请日:

2008.11.13

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention provides substituted bicyclic heteroaryl compounds,5 including, for example, 4-pyrazoIyI-N-arylpyrirnidin-2-arnines and 4-pyrazolyl-N-heteroarylpyτimidin-2-aminesthat modulate the activity of kinases and are useful in the treatment of diseasesrelated to activity of kinases including, for example, immune-related diseases,skin disorders, myeloid proliferative disorders, cancer, and other diseases.formule:(1)

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