PROBLEM TO BE SOLVED: To provide a TRPA1 activity inhibitor which can alleviate a stimulus on skin or mucosa, and an agent for alleviating a feeling of stimulation on skin or mucosa.SOLUTION: A TRPA1 activity inhibitor comprises a compound represented by the following formula (1) [where R1 and R4 independently represent a hydrogen atom or a C1-C3 alkyl group, R2 and R3 independently represent a C1-C3 alkyl group, X is a halogen atom, and a double line of a dotted line and a solid line is a single bond or double bond] as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】皮膚や粘膜による刺激を緩和できるTRPA1活性抑制剤、及び皮膚又は粘膜の刺激感緩和剤の提供。【解決手段】下記式(1)〔式中、R1及びR4はそれぞれ独立して水素原子又は炭素数1~3のアルキル基を示し、R2及びR3はそれぞれ独立して炭素数1~3のアルキル基を示し、Xはハロゲン原子を示し、点線と実線の二重線は単結合又は二重結合を示す。〕で表される化合物を有効成分とするTRPA1活性抑制剤。【選択図】なし
