PROBLEM TO BE SOLVED: To provide a high-pressure steam sterilizer in which the shelter density between a door body and an opening can be secured highly, and that can control the occurrence of unexpected steam leak.SOLUTION: The high-pressure steam sterilizer includes: a chamber arranged in the inside of a sterilizer body a door body that opens and shuts a front surface opening 13 of the chamber a chamber lid 51 that is arranged in the door body and has a toroidal packing that encircles the surrounding of the front surface opening 13 and a chamber lid adjustment screw 49 as a change section that changes the shelter density of the chamber lid 51 and the front surface opening 13.COPYRIGHT: (C)2013,JPO&INPIT【課題】扉体と開口との間の密閉度を高く確保し得て、不測な蒸気漏れの発生を抑制することができる高圧蒸気滅菌器を提供する。【解決手段】滅菌器本体の内部に配置したチャンバーと、チャンバーの前面開口13を開閉する扉体と、扉体に設けられて前面開口13の周囲を包囲する環状パッキンを有するチャンバー蓋51と、チャンバー蓋51と前面開口13との密閉度を変更する変更部としてのチャンバー蓋調整螺子49と、を備えている。【選択図】図5