Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof

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专利权人:

MACROGENICS INC.

发明人:

CHEN FRANCINE ZHIFEN,JOHNSON LESLIE S.,LOO DERYK T.,MOORE PAUL A.,HUANG LING

申请号：

NZ70512811

公开号：

NZ705128A

申请日:

2011.03.01

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is a B7-H3 binding molecule (PRCA157), wherein the molecule is an isolated antibody, an immunoreactive fragment thereof, or a diabody which comprises a variable domain that specifically binds an extracellular domain of B7-H3, wherein said molecule: (a) binds to 4Ig and 2Ig isoforms of B7-H3 that is endogenously expressed on the surface of a cancer cell and (b) comprises the CDR sequences of RASESIYSYLA, NTKTLPE, QHHYGTPPW, SYGMS, VATINSGGSNTYYPDSLKG and HDGGAMDY

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中国工程科技知识中心

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http://www.ckcest.cn/home/