Fisher, Paul,Talukdar, Sarmistha,Emdad, Luni,Das, Swadesh K.
申请号：
AU2017205478
公开号：
AU2017205478A1
申请日:
2017.01.06
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
This invention discloses a method of modulating the survival and stemness of cancer stem cells (CSCs) by modulating the expression of MDA-9/Syntenin (SDCBP), which regulates multiple stemness genes, and controls survival of CSCs by activating the pathways, including without limitation NOTCH1. In one embodiment, the stemness genes that can be regulated by modulating expression or activity of MDA-9/Syntenin (SDCBP) includes, but are not limited to, ALDH1A1, AXL, CD44, DDR1, ID1, ITGB1,
