SCHAEFFTER, Tobias,BEERBAUM, Phillipp,GADDUM, Nicholas Richard,CHOWIENCZYK, Philip Jan
申请号：
GBGB2013/050131
公开号：
WO2013/110929A1
申请日:
2013.01.21
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
Embodiments of the present invention provide a measurement protocol that is able to non- invasively provide a degree of characterisation of aortic stiffness, at least qualitatively. The measurement protocol includes varying intra-thoracic pressure via a series of respiratory manoeuvres, whilst collecting aortic blood flow velocity information using a suitable scanning technique, and from which pulse wave velocity (PWV) may then be found. Plotting PWV against aortic trans-mural pressure variations caused by the changes in intra-thoracic pressure should allow a degree or aortic stiffness characterisation to be performed, in that a diseased aorta should show less variation in PWV with changes in trans-mural pressure than a healthy aorta. Also developed as another embodiment is a magnetic resonance (MR) technique for measuring aortic pulse wave velocity, which is able to achieve high temporal resolution on pulse velocity data capture, and hence lead to accurate PWV calculation. The technique uses a time sliding subtraction of velocity projections obtained from bipolar phase encoding gradients to produce velocity profiles at least every second repetition time TR, and in some variants every TR.La présente invention concerne, dans certains modes de réalisation, un protocole de mesure permettant dobtenir de manière non invasive un degré de caractérisation de la rigidité aortique, au moins qualitativement. Ledit protocole de mesure consiste à faire varier la pression intra-thoracique via une série de manœuvres respiratoires, tout en recueillant des informations sur la vitesse du débit sanguin de laorte au moyen dune technique de numérisation adaptée, permettant ainsi de trouver la vitesse de londe de pouls (VOP). Le tracé de VOP par rapport aux variations de la pression transmurale aortique provoquées par les changements de pression intra-thoracique, devrait indiquer un degré de caractérisation de la rigidité aortique, en ce sens quune aorte atteinte de lésions doit présente
