An orally administering formulation is provided to be able to inhibit wetting, solidification and coloration change and be stable without the combination change even through ibuprofen and an antacid are contained in one granule, and be convenient for preparation with decreased manufacturing cost. An orally administering formulation is obtained by wet-granulating a composition comprising ibuprofen, an antacid, a swelling agent, wherein the antacid is magnesium oxide or sodium hydrogen carbonate, and the swelling agent is at least one selected from the group consisting of lowly substituted hydroxypropylcellulose, carmellose or a salt thereof, croscarmellose sodium, carboxymethyl starch sodium, crospovidone and crystalline cellulose.carmellose sodium.과립을 나누지 않고, 1과립으로 안정화되며, 제조 코스트가 저감된, 성분이 균일한 이부프로펜과 제산제를 함유하는 경구투여용 제제의 제공.이부프로펜, 제산제 및 팽윤제를 함유하는 조성물을 습식 조립함으로써 얻어지는 경구투여용 제제.
