The present invention relates to a combined norovirus and rotavirus vaccine for prevention of norovirus and rotavirus infection and/orviral-induced diarrheal and vomiting dis- easesin man. More specifically, the invention comprises a method ofpreparing combination vaccine compositions comprising norovirus and rotavirus antigens, in particular mixtures of norovirus VLPs and rotavirus recombinant VP6 protein or double-layered VP2/VP6 VLPs. In addition, the invention relates to methods of inducing an immune re- sponse.
