PROBLEM TO BE SOLVED: To provide a therapy progress degree monitoring device and method for the therapy progress degree monitoring for informing of therapy depth of extra-cellular photodynamic therapy in real time during the therapy.SOLUTION: A progress degree monitoring device 1 for photodynamic therapy comprises: irradiation means 30 for irradiating a photosensitizer, which is distributed in extracellular fluid and transcellular fluid of a living body and continuously supplied because of vascular permeability, with excitation light having a wavelength capable of exciting the photosensitizer detection means 30, 20 and 13 for detecting intensity of fluorescence, which is generated in the case where a photosensitizer excited by reaction between excitation light and the photosensitizer is deactivated to a base state, during a detection target period depth calculation means 14 for calculating an index value obtained by estimating volume or depth of a therapy region in real time by using intensity of fluorescence during the detection target period and output means 14, 16 and 17 for outputting the index value to the display unit or a storage unit in real time.COPYRIGHT: (C)2015,JPO&INPIT【課題】細胞外光線力学的治療の治療深度を治療中にリアルタイムに知ることができる治療進行度モニタ装置及びその方法を提供する。【解決手段】光線力学的治療の進行度モニタ装置1である。光感受性物質を励起可能な波長の励起光を、生体の細胞外液,細胞通過液に分布すると共に血管透過性により持続供給される光感受性物質に照射する照射手段30と、励起光と光感受性物質の反応で励起された光感受性物質が基底状態に失活する際に発生する蛍光強度を、検出対象期間中に検出する検出手段30,20,13と、検出対象期間中の蛍光強度を用いて、治療領域の体積又は深度を推定した指標値をリアルタイムで算出する深度演算手段14と、指標値をリアルタイムで表示部又は記憶部に出力する出力手段14,16,17とを備える。【選択図】図7
