Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Российской Академии Медицинских Наук (RU)
发明人:
Середенин Сергей Борисович (RU),Мокров Григорий Владимирович (RU),Крыжановский Сергей Александрович (RU),Лихошерстов Аркадий Михайлович (RU),Столярук Валерий Николаевич (RU),Вититнова Марина Борисовна
申请号：
RU2014105635/04
公开号：
RU2014105635A
申请日:
2014.02.17
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Bis (methoxybenzylaminoalkyl) amines of general formula I where R, R, R, R can be two or three hydrogens, or one or two methoxy groups, n and m may be the same and have the values 2 or 3 or different and have the values n = 2 and m = 3, as well as their physiologically acceptable salts, preferably trihydrochlorides of the general formula II (I * 3HCl). N- (2,3-Dimethoxybenzyl) -N- {2 - [(2,3-dimethoxybenzyl) amino] -ethyl} -1,2-ethanediamine (IIa) trihydrochloride, which has cardiotropic activity. N- (2,4-dimethoxybenzyl) -N- {2 - [(2,4-dimethoxybenzyl) amino] -ethyl} -1,2-ethanediamine (IIb) trihydrochloride, having cardiotropic activity. N- (2,5-dimethoxybenzyl) -N- {2 - [(2,5-dimethoxybenzyl) amino] -ethyl} -1,2-ethanediamine (IIc) trihydrochloride, having cardiotropic activity. N- (2,3,4-Trimethoxysibenzyl) -N- {2 - [(2,3,4-dimethoxybenzyl) amino] ethyl} -1, 2-ethanediamine (IIg), having cardiotropic activity. N- (2,3-dimethoxybenzyl) -N- {3 - [(2,3-dimethoxybenzyl) amino] propyl} -1,3-propanediamine (IId) trihydrochloride, which has cardiotropic activity. N- (2,4-Dimethoxybenzyl) -N- {3 - [(2,4-dimethoxybenzyl) amino] -propyl} -1,3-propanediamine (IIe) trihydrochloride, which has cardiotropic activity. N- (2,3,4-trimethoxybenzyl) -N- {3 - [(2,3,4-trimethoxybenzyl) -amino] propyl} -1,3-propanediamine (IIj) trihydrochloride, which has cardiotropic activity. N- (2,3,4-trimethoxybenzyl) -N- {3 - [(2,3,4-trimethoxybenzyl) -amino] ethyl} -1,3-propanediamine (IIs) trihydrochloride, which has cardiotropic activity. The use of compounds according to 1-9 as substances possessing cardiotropic activity. The method of treatment of cardiovascular diseases by means of effective amounts of compounds according to. 4, 5 and 7.1. Бис(метоксибензиламиноалкил)амины общей формулы Iгде R1, R2, R3, R4 могут быть двумя или тремя водородами, или одной или двумя метоксигруппами, n и m могут быть одинаковыми и иметь значения 2 или 3, или разными и иметь значения n=2 и m=3, а также
