PLASMIDS COMPRISING NUCLEIC SEQUENCES ENCODING IMMUNOGEN AND IMMUNOMODULATING PROTEIN, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USE OF SUCH PLASMIDS IN THE MANUFACTURE OF MEDICAMENTS
Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.