The novel therapeutic potential of Calebin A and compositions thereof to prevent pathological damage to mammalian articular cartilage is disclosed. Specifically a method has been provided for protecting mammalian articular cartilage from pathological damage, said method comprising the step of administering effective dose of Calebin A to mammals in need of said protection.포유동물의 관절 연골에 대한 병리학적 손상을 예방하기 위한 칼레빈 A(Calebin A)의 신규한 치료학적 잠재력 및 이의 조성물이 개시되어 있다.