OLEAS RECALDE, MISHEL ESTEFANIA,RODRIGUEZ FLORES, MARA LASTENIA,PATTARO MARCONDES, LIZANDRA
申请号：
ARP180103918
公开号：
AR114074A1
申请日:
2018.12.28
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
The drug combination includes: (1) the first wide area hydrochloride preparation containing 2.0-12.0% n-octanoate； (2) the second spot ethoxyacetic acid, which contains 6.0-18% ethyl ethoxyacetate, solvent or vehicle； and the manufacturing process In this case, the mixture is synthesized into a single dose such as capsules, compression agents, calcium carbonate tablets, granules and sachets. It also provides ways to prevent and treat pain such as acute pain,And use the combination of drugs to prevent and treat pain such as severe pain. Claim 1: a drug combination characterized by: (a) a first prepared extensively released hydrochloride containing 2.0% to 12.0% of the hydrochloride as the active ingredient of the first drug, and 30% to 40% of the pharmaceutically acceptable precursor chemicals； And (b) a second stereoxyethanol containing 6.0-18.0% ethoxyethanol as the active ingredient of the second drug, and 40-52% of the pharmaceutical acceptable precursor chemicals,The P / P ratio of vehicles with acceptable solvents or drugs is the percentage of the combined total weight, and the solvent or vehicle is not within the range of the combined total weight. Requirements 21: etorioxyb medical form of immediate relevant relevant, compiles de: 10.3-31.0% P / P de etorioxyb, 13.8-21.2% P / P de meglumina, 5.4-8.6% P / P de alboximet de SOD, 44.8-50.0% P / P de cellulosic microcrystals, 1.4-4.3% P / P de polyvildirdona, 3.4-5, The content of magnesium stearate is 2.p/p, the content of acceptable dyes in medicine is 0.2-0.4%, ethanol and water in solvent or vehicle；P / P refers to the total weight of the second immediate release formulation, which is not included in the total weight of the solvent or vehicle.Combinación farmacéutica que comprende: i) una primera formulación de tramadol clorhidrato de liberación extendida que contiene desde 2,0% a 12,0% p/p de tramadol clorhidrato, y ii) una segunda formulación de etoricoxib de liberación inmediata que contiene desde 6,0% a 1
