The invention relates to a patient support system developed to position and support a patient lying on the support system, for example at X-Ray systems, especially Cardio/Vascular systems comprising a frame that, in use, is mounted to a floor, an upright column mounted to the frame and supporting a substantially rectangular table top extending in the plane of the rectangle and that is movable longitudinally with respect to the column to accommodate a patient, the patient support system comprising a guiding device developed to guide the column from a first position with respect to the floor to a second position with respect to the floor, wherein in use the guiding device is arranged to guide the column in a rectilinear path between the first and the second position. The invention further relates to a guiding device for use in a patient table and to the use of a guiding device and/or a patient table.