Ann-Kristin Mossberg;Jenny Petterson-Kastberg;Catharina Svanborg;Kenneth Hun Mok
发明人:
Catharina Svanborg,Kenneth Hun Mok,Ann-Kristin Mossberg,Jenny Petterson-Kastberg
申请号:
US13143785
公开号:
US20120028883A1
申请日:
2010.01.08
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A method for preparing a biologically active complex, said method comprising a recombinant protein having the sequence of α-lactalbumin, such as human α-lactalbumin or a fragment thereof but which lacks intra-molecular disulfide bonds, and oleic acid, and process for preparing this are described and claimed. The recombinant protein suitably has cysteines found in the native protein changed to other amino acids, such as alanine. Improvements in recombinant expression, process rationalisation and yields of biologically active complexes, as well as the complexes obtained are also described and claimed.