A ureteral access system includes a ureteral probe and a sheath. The ureteral probe has a proximal end, a tapered distal end portion, and an exterior wall with a longitudinal channel formed in the ureteral probe that communicates with a proximal port formed in the exterior wall and with a distal port formed in the exterior wall. The ureteral probe is provided with a split opening extending from the proximal port to the distal port. The longitudinal channel is sized to receive a guide wire that is insertable through a urethra and into a ureter. The sheath is sized for placement over the ureteral probe.