IMMUNOLOGIC CONSTRUCTS AND METHODS

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专利权人:

VAXINNATE CORPORATION

发明人:

SONG, LANGZHOU,LIU, GE,UMLAUF, SCOTT,KAVITA, UMA,LI, HONG,LIU, XIANGYU,WEAVER, BRUCE,TUSSEY, LYNDA

申请号：

EP12845292

公开号：

EP2773674A4

申请日:

2012.08.22

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity and/or improve folding of the protein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/