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METHOD OF PREVENTING VIRUS:CELL FUSION BY INHIBITING THE FUNCTION OF THE FUSION INITIATION REGION IN RNA VIRUSES HAVING CLASS I MEMBRANE FUSOGENIC ENVELOPE PROTEINS
专利权人:
发明人:
申请号:
HK11106193.9
公开号:
HK1152082A
申请日:
2011.06.15
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, a step required for viral infection). The present invention particularly relates to the families of RNA viruses, including the arenaviruses, coronaviruses, filoviruses, orthomyxoviruses, paramyxoviruses, and retroviruses, having Class I membrane fusion proteins as the fusion proteins that mediate this fusion process. The present invention provides for a method of identifying a conserved motif or domain called the fusion initiation region (FIR) in these viruses. The present invention further provides for methods of preventing infection by such viruses, by interfering with their FIR. The present invention further provides for methods of treatment and prophylaxis of diseases induced by such viruses.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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