Methods are provided for increased rates of weight loss while reducing the discomfort caused by dieting. An initial daily dose of HCG of 200 IU or greater is administered to a patient on a reduced calorie diet plan for weight loss. The reduced calorie diet plan includes limits on the amounts of protein, vegetables and fruits that may be eaten based upon caloric content and sugar levels in the vegetables and fruit. In one embodiment, the reduced calorie diet plan limits caloric intake to 500-800 calories per day. The patient is monitored and the daily HCG dose may be adjusted upward as needed to control hunger and maintain patient comfort.