For technical field the present invention relates to the method for transgene mammal, the active material and screening for studying T cell therapeutic effect can be used for treating immunological diseases, preferably autoimmune disease. It include encoding T cell receptor β chains MOG-binding (TCR) the present invention relates to a kind of expression construct of transgene non-human mammal transgenosis, a kind of of T cell receptor (TCR) albumen or nucleic acid encodes that the inhuman mammal of the transgenosis is namely isolated in the TCR and a kind of screening for one or more factors participates in T cells in the therapeutic effect of immunological diseases.
