The present invention relates to the GPR119 receptor agonists: 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)- N , N- dimethylbenzamide； 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)- N -methylbenzamide； and 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)benzamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as a single pharmaceutical agent or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder； a condition ameliorated by increasing secretion of an incretin； a condition ameliorated by increasing a blood incretin level； a condition characterized by low bone mass； a neurological disorder； a metabolic-related disorder； type 2 diabetes； obesity； and complications related thereto.本発明は、GPR119レセプターアゴニスト:3-フルオロ-4-(5-フルオロ-6-(4-(3-(2-フルオロプロパン-2-イル)-1,2,4-オキサジアゾール-5-イル)ピペリジン-1-イル)ピリミジン-4-イルアミノ)-N,N-ジメチルベンズアミド；3-フルオロ-4-(5-フルオロ-6-(4-(3-(2-フルオロプロパン-2-イル)-1,2,4-オキサジアゾール-5-イル)ピペリジン-1-イル)ピリミジン-4-イルアミノ)-N-メチルベンズアミド；および3-フルオロ-4-(5-フルオロ-6-(4-(3-(2-フルオロプロパン-2-イル)-1,2,4-オキサジアゾール-5-イル)ピペリジン-1-イル)ピリミジン-4-イルアミノ)ベンズアミド、ならびにその薬学的に受容可能な塩、溶媒和物、および水和物に関する。
