Disclosed are immunogenic compositions comprising a modified live bovine viral diarrhea virus type lb (BVDV lb) and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents. In particular the invention provides immunogenic compositions and methods for preventing treating managing and/or ameliorating a viral or microbial infection or one or more symptoms thereof including for example those infections giving rise to shipping fever bovine respiratory disease complex and/or bovine viral diarrhea particularly in susceptible or infected animals.
