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Polyarginine-modified liposome having nuclear entry ability
专利权人:
Hideyoshi Harashima
发明人:
Hideyoshi Harashima,Shiroh Futaki,Kentaro Kogure
申请号:
US11396081
公开号:
US08592210B2
申请日:
2006.03.31
申请国别(地区):
US
年份:
2013
代理人:
摘要:
With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.
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